منابع مشابه
Early bisphosphonate treatment in infants with severe osteogenesis imperfecta.
OBJECTIVE To evaluate prospectively the efficacy of bisphosphonate treatment in infants with severe forms of osteogenesis imperfecta (OI). STUDY DESIGN Of 10 children (6 females) with OI type III, 5 (group A) started treatment (2 mg/kg neridronate administered intravenously for 2 consecutive days, every 3 months) just after diagnosis at birth and 5 (group B) after 6 months. Ten untreated chil...
متن کاملRecurrence risks and prognosis in severe sporadic osteogenesis imperfecta.
A study was carried out in the United Kingdom of patients with severe osteogenesis imperfecta (OI), born with fractures to normal parents, in order to determine recurrence risks. A total of 105 cases from 98 families survived the perinatal period and 60 cases from 57 families were stillborn or died during the first week of life. The majority of the perinatal survivors correspond to the overlapp...
متن کاملOsteogenesis imperfecta
Keywords Disease name and synonyms Definition/Diagnosis criteria Differential diagnosis Frequency Clinical description Etiology Diagnostic methods Management Treatment Genetic counselling References Abstract Osteogenesis imperfecta (OI) is a group of inherited diseases responsible for varying degrees of skeletal fragility. Minimal trauma is sufficient to cause fractures and bone deformities. A ...
متن کاملCyclic administration of pamidronate in children with severe osteogenesis imperfecta.
BACKGROUND Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of treatment with a bisphosphonate on bone resorption. METHODS In an uncontrolled observational study involving 30 children who were 3 to 16 years old and...
متن کاملDecreased Bone Material Strength in Severe Osteogenesis Imperfecta (oi)
Bone fragility in OI is believed to result from a combination of bone mass deficiencies and compromised material properties of the bone tissue. Little data, however, is available to describe bone material properties in individuals with OI. At the sub-microstructural scale, nanoindentation studies have found that the elastic modulus (E) of bone tissue is lower in children with severe OI (type II...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1978
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.6113.620-a